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KMID : 0894520090130010013
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Development & Reproduction
2009 Volume.13 No. 1 p.13 ~ p.23
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Perspective on the Role of Mitochondrial Dynamics in the Nervous System Development
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Cho Bong-Ki
Sun Woong
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Abstract
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Recent advances in cell biological and genetic researches have revealed that mitochondrial morphology is highly dynamic and regulated by multiple molecular factors including dynamin-related proteins (DRPs). Considering that the mitochondria play critical roles in the cellular metabolism via ATP synthesis, calcium homeostasis in cooperation with endoplasmic reticulum, and apoptosis, the failure of mitochondrial dynamics is infrequently related to the failure in the normal growth and cellular integrity. In this respect, alteration of mitochondrial dynamics may greatly affect the development of nervous system. In this short review, we discussed molecules involved in the control of mitochondrial dynamics, and provide some perspectives on their significance in the neuronal development.
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KEYWORD
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Mitochondria, Dynamics, Dynamin-related proteins, Neuron, Development
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